ONCO 205 - NON-INFECTIOUS CANCER GENETICS & GENOMICS

[3 Credits]

This course will cover molecular and cellular (non-infectious) mechanisms of malignant transformation and will explain how basic-and preclinical-cancer research contributed to new anti-cancer therapies with special emphasis on anti-cancer personalized medicine. At the end of the course, students are expected to understand basic molecular and cellular factors responsible for malignant transformation, tumor development and progression to metastatic disease. These multi-factorial/multi-step evolution of neoplastic disease include: 1) genomic instability; 2) dysregulation of fundamental growth mechanisms (cellular oncogenes and tumor suppressors); 3) tumor cell survival; 4) tumor stem cells, drug resistance, as well as 5) introduction to Biostatistics and Bioinformatic computational tools and resources for omics data analyses with special emphasis on cancer genome and transcriptome.